Dr. Leng Chee Chang

Assistant Professor

Natural Products Chemistry/Biochemistry

Office: SSB 152B

Phone: (218) 726–7346

Fax: (218) 726–7394

E-mail: lcchang@d.umn.edu

Personal Webpage: http://www.d.umn.edu/~lcchang

•Ph.D. 1998 – University of Illinois at Chicago

•Postdoctoral Research Associate – University of Minnesota

Research Interests

• Evaluation of Natural Products as anticancer (in particular protein kinase inhibitors) and antimycobaterial agents
• To isolate and elucidate the structures of purified, bioactive compounds from such extracts using spectroscopic methods and their mechanisms of action.
• To study herbal products or Traditional Medicine reputed to reduce or control cancer or alleged to improve human health.

Representative Publications

1. Chang, L. C., Noel Whitakker, and Bewley, C. A. “Crambescidins 826 and 447: new polycyclic guanidine alkaloids from the marine sponge Monanchora sp.” J. Nat. Prod. (In press) (2003).
2. Chang, L. C. and Bewley, C. A. “Potent inhibition of HIV-1 fusion by cyanovirin-N requires only a single high affinity carbohydrate binding site: Characterization of low affinity carbohydrate binding site knockout mutants.” J. Mol. Biol.318, 1-8 (2002).
3. Chang, L. C., Otero-Quintero, S., Hooper, J. N. A., and Bewley, C. A. “Batzelline D and isobatzelline E from the Indopacific sponge Zyzzya massalis.” J. Nat. Prod. 65, 776-778 (2002).
4. Chang, L. C. and Kinghorn, A. D. “Flavonoids as cancer chemopreventiveagents. In: Bioactive Compounds from Natural Sources: Isolation, Characterisation and Biological Properties.” Ed. C. Tringali, Taylor and Francis, London, pp. 161-187 (2001).
5. Chang, L. C., Otero-Quintero, S., Nicholas, G. M., and Bewley, C. A. “Phyllolactones A-E: new bishomoscalarane sesterterpenes from the marine sponge Phyllospongia lamellosa.” Tetrahedron57, 5731-5738. (2001).

Education

• Ph.D (Pharmacognosy), Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 1998.
• M.S. (Chemistry), Department of Chemistry, National University of Malaysia, Sabah, Malaysia, 1992.
• B.S. (Chemistry), National University of Malaysia, Sabah, Malaysia, 1988.

Jobs and Academic Positions

• Assistant Professor, University of Minnesota Duluth, Duluth, MN, August, 2003 - Present
• Ruth L. Kirschstein National Research Service Award Fellow (NRSA), University of Minnesota, Minneapolis, 2002 - 2003.
• Intramural Research Training Award Fellow (IRTA), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, 2000 - 2001.
• Post-Doc, University of Illinois at Chicago, 1998 - 2000.