Dr. Venkatram Mereddy

Assistant Professor

Medicinal Chemistry

Organic Chemistry

Office: Chem 223

Phone: (218)726–6766

Fax: (218) 726–7394

E-mail: vmereddy@d.umn.edu

• Ph. D. 1996 Indian Institute of Technology Kanpur, India

• Postdoctoral Research Associate, Purdue University

Research Interests

• Discovery of new synthetic methods and reagents
• Stereoselective total syntheses of new generation anticancer molecules and the mechanism based design of analogs
• Rational design, syntheses and biological evaluation of novel antifolates as antibacterial and antineoplastic agents
• Development of methodologies for targeted drug delivery

Representative Publications

1. P. V. Ramachandran, Debarshi Pratihar, Debanjan Biswas, Amit Srivastava, "Syntheses of Novel Functionalized Trisubstituted Allylboronates via Hosomi-Miyaura Borylation of Functionalized Allyl Acetates" Org. Lett. 2004 , 6 , 481.
2. P. V. Ramachandran, Boduri Prabhudas, J. Subash Chandra, M. Venkatram Reddy Diastereoselective dihydroxylation and regioselective deoxygenation of dihydropyranones: A novel protocol for the stereoselective synthesis of C 1 -C 8 and C 15 -C 21 subunits of (+)-Discodermolide.  J. Org. Chem. 2004 , 69 , 6294.
3. P. V. Ramachandran, Kamlesh J. Padiya, Vivek Rauniyar, M. Venkatram Reddy, Herbert C. Brown   "Asymmetric Synthesis of g -Perfluorinated Butyrolactones via Organoboranes"   Tetrahedron Lett . 2004 , 44 , 1015.
4. P. V. Ramachandran, Bodhuri Prabhudas, J. Subash Chandra, M. Venkatram Reddy, Herbert C. Brown "Preparative-Scale Synthesis of Both Antipodes of B- g , g -Dimethylallyldiisopinocampheylborane: Application for the Synthesis of C 1 -C 6 Subunit of Epothilone" Tetrahedron Lett . 2004 , 44 , 1011.
5. P. V. Ramachandran, Michael T. Rudd, Thomas E. Burghardt, M. Venkatram Reddy "Vinylalumination for the Synthesis of Functionalized Allyl Alcohols, Vinylepoxides, and ?-Alkylidene-?-hydroxy- g -lactones" J. Org. Chem. 2003 , 68 , 9310.

Education

• Ph.D., Chemistry, Indian Institute of Technology, Kanpur, India, 1996
• M.S., Chemistry, National Institute of Technology, Warangal, India, 1990
• B.S., Forestry, Osmania University, Hyderabad, India, 1987

Jobs and Academic Positions

• Assistant Professor, University of Minnesota Duluth, Duluth, MN, (July 2004 – Present)
• Assistant Research Scientist, Herbert C. Brown Center for Borane Research, Purdue University, West Lafayette, IN (2001–2004)
• Research Associate, Herbert C. Brown Center for Borane Research, Purdue University, West Lafayette, IN (2000– 2001)
• Postdoctoral Research Associate, Purdue University, West Lafayette, IN (1997 – 2000