Dr. Jon Rumbley

Assistant Professor

Biochemistry

Office: SSB 253B/KPlz 342

Phone: (218) 726–7423

Fax: (218) 726–7394

E-mail: jrumbley@d.umn.edu

Personal Webpage: http://www.d.umn.edu/~jrumbley

•Ph.D. 1995 University of Illinois, Champaign-Urbana, IL




Research Interests

Representative Publications

  1. Rumbley, J.N., Hoang, L., Mayne, L., and Englander, S.W. (2001) An amino acid
    code for protein folding. Proc.Natl.Acad.Sci., 98, 105-112.
  2. Rumbley, J.N., Hoang, L., and Englander, S.W. (2002) Recombinant equine
    cytochrome c in E. coli: high level expression, characterization, and folding and
    assembly mutants. Biochemistry, 41, 13894-13901.
  3. Englander, S.W., Mayne, L., and Rumbley, J.N. (2002) Submolecular cooperativity
    produces multi-state protein unfolding and refolding. Biophys. Chem., 101-
    102, 57-65.
  4. Kranz, B.A., Mayne, L., Rumbley, J.N., Englander, S.W., and Sosnick, T.R. (2002)
    Fast and slow intermediate accumulation and the initial barrier mechanism in
    protein folding. J. Mol. Biol., 324, 359-371.
  5. Krishna, M. M. G., Lin, Y., Rumbley, J.N., and Englander, S.W. (2003)
    Cooperative omega loops in cytochrome c: Role in folding and function. J.
    Mol. Biol., 331, 29-36.
  6. Maity, H., Lim, W., Rumbley, J.N., and Englander, S.W. (2003) Protein hydrogen
    exchange mechanism: local fluctuations. Protein Sci., 12, 153-160.
  7. Liu, W., Rumbley, J.N., Englander, S.W., and Wand, A.J. (2003) Fast dynamics
    in reduced and oxidized cytochrome c. J. Am. Chem. Soc. (submitted).
  8. Rumbley, J.N., and Englander, S.W. (2003) The protein unfolded state remembers
    the native topology. (manuscript in preparation).

Education