Dynamics Imaging of Biomolecular Assemblies

 

Publications

 

Edited Books:

  1. Natural Biomarkers for Cellular Metabolism: Biology, Techniques, and Applications. Vladimir V. Ghukasyan and Ahmed A. Heikal (Editors), Taylor & Francis, CRC Press (October 7, 2014, 408 Pages, ISBN: 9781466509986), Series in Cellular and Clinical Imaging (Senior Editor: Ammasi Periasamy).

Invited Reviews

  1. Heikal, A.A. Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies. Biomarkers in Medicine, 4(2): 241-263 (2010).

Invited Book Chapters

  1. Heikal, A.A. A Multiparametric fluorescence approach for biomembrane studies. In, “Advances in Planar Lipid Bilayers and Liposomes”, Editor: Iglic A, Volume 13, Elsevier, Inc.; p. 169-197 (May 2011).

  2. Heikal, A.A. A Multiparametric imaging of cellular coenzymes for monitoring metabolic and mitochondrial activities. In, “Annual Review in Fluorescence 2010”, Editor: Chris D.Geddes, Springer, 2011.

Publications in Peer-Review Journals

  1. Heikal, A.A. 2014. Time-resolved fluorescence anisotropy and fluctuation correlation analysis of major histocompatibility complex class I proteins in fibroblast cells. Methods; Volume 66: 283 - 291..

  2. Solntsev P.V., K.L. Spurgin, J.R. Sabin, A.A. Heikal, V.N. Nemykin. 2012. Photoinduced charge transfer in short-distance ferrocenylsubphthalocyanine dyads. Inorg. Chem., 51(12):6537-6547.

  3. Yu, Q. and A.A. Heikal. 2009. Two-photon autofluorescence dynamics imaging reveals sensitivity of intracellular NADH concentration and conformation to cell physiology at the single-cell level. Journal of Photochemistry and Photobiology (B): Biology, 95: 46–57; Press Release.

  4. Ariola, F.S., Z. Li, C. Cornejo, R. Bittman, and A.A. Heikal. 2009. Membrane fluidity and lipid order in ternary giant unilamellar vesicles using a new Bodipy-cholesterol derivative. Biophysical Journal, April Issue, 96(7), 2696–2708.

  5. Davey, A.M., K.M. Krise, E.D. Sheets, and A.A. Heikal.  2008.  Molecular perspective of antigen-mediated mast cell signaling. Journal of Biological Chemistry, 283:7117-7127. Press Release.

  6. Davey, A.M., R.P. Walvick, Y. Liu, A.A. Heikal, and E.D. Sheets.  2007.  Membrane order and molecular dynamics associated with IgE receptor crosslinking in mast cells.  Biophysical Journal, 92:343-355. 

  7. Yu, Q., M. Proia, and A.A. Heikal. 2008. Integrated biophotonics approach for noninvasive, multiscale studies of biomolecular and cellular biophysics. Journal of Biomedical Optics, 13:041315.

  8. Larson, D.R., H. Ow, H.D. Vishwasrao, and A.A. Heikal, U. Wiesner, and W.W. Webb. 2008. Silica nanoparticle architecture determines radiative properties of encapsulated fluorophores. Chemistry of Materials, 20:2677-2684.

  9. Liu, Y., H.-R. Kim, and A.A. Heikal. 2006. Structural basis of fluorescence fluctuation dynamics of green fluorescent proteins in acidic environments. Journal of Physical Chemistry (B), 110:24138-24146.

  10. Ariola, F.S., Mudaliar, D.J., R.P. Walvick, and A.A. Heikal. 2006. Dynamics of lipid phases and lipid-marker interactions in model biomembranes. Physical Chemistry Chemical Physics, 8(39): 4517-4529.

  11. Shi, K., A.A. Heikal, and Z. Liu. 2006. A single-shot approach for measuring two-photon action cross-section of fluorescent markers. Optics Express, 14(19):8722-8727.

  12. Vishwasrao, H.D., A.A. Heikal, K.A. Kasischke, and W.W. Webb.  2005.  Conformational dependence of intracellular NADH on metabolic state revealed by associated fluorescence anisotropy.  Journal of Biological Chemistry, 208(26):25119-252126; Issue cover and Press Release.

  13. Hess, S.T., A.A. Heikal, and W.W. Webb. 2004. Fluorescence photoconversion kinetics in novel green fluorescent protein pH sensors (pHluorins).  Journal of Physical Chemistry (B), 108(28):10138-10148; Issue cover.

  14. Korlach, J., D. Baird, A.A. Heikal, K.R. Gee, G.R. Hoffman, and W.W. Webb.  2004. Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled g-phosphate linked GTP analogs. Proceedings of the National Academy of Sciences (USA), 101(9):2800-2805.

  15. Hess, S.T., E.D. Sheets, A. Wagenknecht-Wiesner, and A.A. Heikal. 2003. Quantitative analysis of the fluorescence properties of intrinsically fluorescent proteins in living cells. Biophysical Journal, 85:2566–2580.

  16. Huang, S., A.A. Heikal, and W.W. Webb. 2002. Two-photon fluorescence spectroscopy and microscopy on NAD(P)H and flavoprotein. Biophysical Journal, 82(5):2811-2825.

  17. Hess, S.T., S. Huang, A.A. Heikal, and W.W. Webb. 2002. Biological and chemical applications of fluorescence correlation spectroscopy: a review. Biochemistry, 41(3):697-705.

  18. Heikal, A.A., S.T. Hess, and W.W. Webb. 2001.  Multiphoton spectroscopy and excited state dynamics of enhanced green fluorescent protein (EGFP): acid-base specificity. Chemical Physics, 274(1):37-55.

  19. Heikal, A.A., S.T. Hess, G.S. Baird, R.Y. Tsien, and W.W. Webb. 2000. Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine). Proceedings of the National Academy of Sciences (USA), 97(22):11996-12001.

  20. Schwille, P., S. Kummer, A.A. Heikal, W.E. Moerner, and W.W. Webb.  2000. Fluorescence correlation spectroscopy reveals fast optical excitation-driven intramolecular dynamics of yellow fluorescent proteins. Proceedings of the National Academy of Sciences (USA), 97(1):151-156. 

  21. Kuebler, S.M., M. Rumi, T. Watanabe, K. Braun, B.H. Cumpston, A.A. Heikal, L.L. Erskine, S. Thayumanavan, S. Barlow, S.R. Marder, and J.W. Perry.  2001. Optimizing two-photon initiators and exposure conditions for three-dimensional lithographic microfabrication.  Journal of Photopolymer Science and Technology, 14(4):657-668.

  22. Rumi, M., J.E. Ehrlich, A.A. Heikal, J.W. Perry, S. Barlow, Z. Hu, D. McCord-Maughon, T.C. Parker, H. Roeckel, S. Thayumanavan, S.R. Marder, D. Beljonne, and J.-L. Bredas. 2000.  Structure-property relationships for two-photon absorbing chromophores: bis-donor diphenylpolyene and bis(styryl)benzene derivatives. Journal of the American Chemical Society, 122(39):9500-9510.

  23. Cumpston, B.H., S.P. Ananthavel, S. Barlow, D.L. Dyer, J.E. Ehrlich, L.L. Erskine, A.A. Heikal, S.M. Kuebler, I.-Y.S. Lee, D. McCord-Maughon, J. Qin, H. Rockel, M. Rumi, X.-L. Wu, S.R. Marder, and J.W. Perry. 1999.  Two-photon polymerization initiators for three-dimensional optical data storage and microfabrication. Nature (London), 398(6722):51-54.

  24. Albota, M., D. Beljonne, J.-L. Bredas, J.E. Ehrlich, J-Y. Fu, A.A. Heikal, S.T. Hess, T. Kogej, M.D. Levin, S.R. Marder, D. McCord-Maughon, J.W. Perry, H. Rockel, M. Rumi, G. Subramaniam, W.W. Webb, X.-L. Wu, and C. Xu.  1998.  Design of organic molecules with large two-photon absorption cross sections. Science, 281(5383):1653-1656.

  25. Heikal, A.A., J.S. Baskin, L. Banares, and A.H. Zewail. 1997.  Structural effects on the isomerization dynamics of trans-stilbenes: IVR, microcanonical reaction rates, and the nature of the transition state. Journal of Physical Chemistry (A), 101(4):572-590.

  26. Heikal, A.A., S.H. Chong, J.S. Baskin, and A.H. Zewail. 1995. Microscopic friction and solvation in barrier crossing: isomerization of stilbene in size-selected hexane clusters, Chemical Physics Letters, 242(4,5):380-389.

  27. Kim, S.K., J.J. Breen, D.M. Willberg, L.W. Peng, A.A. Heikal, J.A. Syage, and A.H. Zewail.  1995. Solvation ultrafast dynamics of reactions. 8. Acid-base reactions in finite-sized clusters of naphthol in ammonia, water, and piperidine. Journal of Physical Chemistry, 99(19):7421-7435.

  28. Lienau, C., A.A. Heikal, and A.H. Zewail. 1993.  Picosecond dynamics of hexane-solvated trans-stilbene. Chemical Physics, 175(1):171-191.

  29. Banares, L., A.A. Heikal, and A.H. Zewail. 1992. Ultrafast dynamics of isomerization reactions: structural effects in stilbene(s). Journal of Physical Chemistry, 96(11):4127-4130.

  30. Heikal, A.A., L. Banares, D.H. Semmes, and A.H. Zewail. 1991. Real-time dynamics of vibrational predissociation in anthracene-argonn (n = 1, 2, 3). Chem. Phys, 156(2):231-250.

  31. Breen, J.J., L.W. Peng, D.M. Willberg, A.A. Heikal, P. Cong, and A.H. Zewail. 1990.  Real-time probing of reactions in clusters. Journal of Physical Chemistry, 92(1):805-807.

 

Papers Published in Books or Proceedings

  1. Liu, Y., F.S. Ariola, H.-R. Kim, Q. Yu, R. Walvick, and A.A. Heikal. Two-photon excited-state and conformation dynamics of NADH binding with dehydrogenases. In Femtochemistry and Femtobiology, VII, A.W. Castleman and M. L. Kimble (Editors), Elsevier, pp. 396-401 (2006). 

  2. Cumpston, B.H., S.P. Ananthavel, S. Barlow, D.L. Dyer, J.E. Ehrlich, L.L. Erskine, A.A. Heikal, S.M. Kuebler, I.-Y.S. Lee, D. McCord-Maughon, J. Qin, H. Rockel, M. Rumi, X.-L. Wu, S.R. Marder, and J.W. Perry. Two-photon polymerization initiators for three-dimensional optical data storage and microfabrication. In Selected Papers in Multiphoton Excitation Microscopy (SPIE Milestone Vol. MS175), B.R. Masters (Editor), SPIE Publications, pp.212-215 (2003).

  3. Albota, M., D. Beljonne, J.-L. Bredas, J.E. Ehrlich, J.-Y. Fu, A.A. Heikal, S.T. Hess, T. Kogej, M.D. Levin, S.R. Marder, D. McCord-Maughon, J.W. Perry, H. Rocket, M. Rumi, G. Subramaniam, W.W. Webb, X.-L. Wu, and C. Xu. Design of organic molecules with large two-photon absorption cross sections. In Selected Papers in Multiphoton Excitation Microscopy (SPIE Milestone Vol. MS175), B.R. Masters (Editor), SPIE Publications, pp.507-510 (2003).

  4. Heikal, A.A., S.T. Hess, E.D. Sheets, and W.W. Webb. Mutation-photophysics relationships in intrinsically fluorescent proteins. In Femtochemistry and Femtobiology: Ultrafast dynamics in molecular science, A. Douhal and J. Santamaria (Editors), World Scientific, pp. 774-781 (2002).