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Carcinogens,
Reproductive Toxins
or Highly Toxic
Chemicals
The chemicals listed below are extremely hazardous. Workers must
have knowledge of the dangers of these chemicals prior to use, and
documentation of training in safe working procedures.
Biologically active compounds
- protease inhibitors (e.g. PMSF, Aprotin,
Pepstatin A, Leopeptin);
- protein synthesis inhibitors (e.g.
cycloheximide, Puromycin);
- transcriptional inhibitors (e.g. a-amanitin and
actinomycin D);
- DNA synthesis inhibitors (e.g. hydroxyurea,
nucleotide analogs (i.e.
- dideoxy nucleotides), actinomycin D,
acidicolin);
- phosphatase inhibitors (e.g. okadaic acid);
- respiratory chain inhibitors (e.g. sodium
azide);
- kinase inhibitors (e.g. NaF);
- mitogenic inhibitors (e.g. colcemid);
- mitogenic compounds (e.g. concanavalin A)
Castor bean (Ricinus communis) lectin: Ricin A, Ricin B, RCA toxins
Diisopropyl fluorophosphate: highly toxic cholinesterase inhibitor; the
antidote, atropine sulfate and 2-PAM (2-pyridinealdoxime methiodide)
must be readily available
Jaquirity bean lectin (Abrus precatorius)
N-methyl-N'-nitro-N-nitrosoguanidine: carcinogen (this chemical forms
explosive compounds upon degradation)
Phalloidin from Amanita Phalloides: used for staining actin filaments
Retinoids: potential human teratogens
Streptozotocin: potential human carcinogen
Urethane (ethyl carbamate): an anesthetic agent, potent carcinogen and
strong teratogen, volatile at room temperature |
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