Integrated Biosciences Graduate Program

Haim Einat, Ph.D.

Present status

Assitant Professor, College of Pharmacy, Duluth, University of Minnesota

Senior Affiliate Member, Pharmacology Graduate Program, University of Minnesota

Member, Integrated Biosciences Graduate Program, University of Minnesota Duluth

Education

Post-Doc (2001-2004) Fellow, behavioral specialist – LMP, NIMH

Ph.D. (2001) Ben Gurion University of the Negev, Israel.

M.Sc. Biomed. and Behav. Sci. (1995) McMaster University, Canada.

M.Sc. Zoology (1991) Tel-Aviv University, Israel.

B.Sc. Biology (1989) Tel-Aviv University, Israel.

B.Med.SC. (1985) Hebrew University of Jerusalem, Israel.

Research

My research utilizes animal models to explore the biological basis of affective and anxiety disorders and develop better treatments for these devastating diseases. I work on the development and validation of better animal models for these diseases and employ both established and novel models to explore behaviorally specific intracellular molecules and pathways that are implicated in affective disorders and its treatments. I am currently teaching CNS pharmacology and advanced psychopharmacology course to pharmacy students.

Sample Publications

Reviews

• Einat H (In Press) Modeling facets of mania – new directions related to the notion of endophenotypes (Journal of Psychopharmacology).
• Einat H , Belmaker RH, Manji HK (2003) New approaches to modeling bipolar disorder – from face to construct validity. Psychopharmacology Bulletin 37(1): 47-63.

Peer Reviewed Research papers (* equal contribution)

• Einat H, Yuan PX, Manji KH (2005) Anxiety-like behaviors and reduced mitochondrial Bcl-2 levels in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behavioral Brain Research (e-publsihed ahead of print).
• * Gould TD, *Einat H , Bhat R, Manji KH (2004). AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. Int. Journal of Neuropsychopharmacology 7:1-4.
• Einat H , Yuan PX, Gould TD, Li J, Du J, Manji HK, Chen G. (2003)The role of the extracellular signal-regulated kinase signaling pathway in mood-modulation. Journal of Neuroscience 23 (19) 7311-7316
• Einat H , Clenet F, Shaldubina A, Belmaker RH, Bourin M (2001) The antidepressant activity of inositol in the forced swim test involves 5-HT 2 receptors. Behavioral Brain Research 118(1) 77-83.
• Einat H , Einat D, Allan M, Talangbayan H, Tsafnat T, and Szechtman H, (1996) Associational and nonassociational mechanisms in locomotor sensitization to the dopamine agonist quinpirole. Psychopharmacology, 127:95-101.