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ILSC Monthly Seminar: October 2011


January: Michael Taylor
February: Marna Yandeau-Nelson
March: Paul Lockman
April: Martin Gruebele


January: David D. Thomas
February: Elizabeth Austin-Minor
March: Juliette Lecomte
April: David Millar
May: Lukas Tamm
September: David Millar
September: Dongping Zhong
October: Jonathan V. Rocheleau
November: Yevgenya Grinblat
December: Michael Graner


January: Clay Carter
February (a): Anne Kenworthy
February (b): Jennifer Liang
March: Joe Johnson
April: Marco Ciufolini
May: Gary Pielak
October: Matthew Andrews
December: Andrew Skildum


November: Rui Wang
October: Marshall Hampton

Genes That Control Hibernation in Mammals

Speaker: Dr. Matthew T. Andrews; Professor, Department of Biology; University of Minnesota Duluth

Time/Place: Thursday, Oct. 20th at 3:00 pm, 130 SMed

Abstract: Hibernation is a natural adaptation that allows certain mammals to survive physiological extremes that would result in death in humans. The fundamental trait present in natural hibernators is greatly reduced body temperature, metabolism and respiration — conditions that buy precious time in cases of myocardial ischemia, traumatic injury and cardiac arrest. High-throughput instrumentation and advances in computational power have allowed us to identify genes that control the hibernation phenotype and link their expression to organ function under extreme conditions. We have identified genes that are expressed in active and hibernating thirteen-lined ground squirrels (Ictidomys tridecemlineatus) at six points throughout the year by high-throughput cDNA sequencing using the Roche 454 and Illumina sequencing systems. The 454 platform generates individual reads with lengths up to 500 bases and the Illumina High-Seq system produces 10 million reads per reaction. These massive sequencing platforms have generated statistically high numbers of cDNA sequences that are used to determine patterns of gene expression throughout the hibernation season. This new approach of measuring gene activity opens the door for investigating other novel phenotypes in the vast world of "non-model" organisms. This work was funded by NIH grant 1RC2HL101625

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