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ILSC Monthly Seminar: February 2011


January: Michael Taylor
February: Marna Yandeau-Nelson
March: Paul Lockman
April: Martin Gruebele


January: David D. Thomas
February: Elizabeth Austin-Minor
March: Juliette Lecomte
April: David Millar
May: Lukas Tamm
September: David Millar
September: Dongping Zhong
October: Jonathan V. Rocheleau
November: Yevgenya Grinblat
December: Michael Graner


January: Clay Carter
February (a): Anne Kenworthy
February (b): Jennifer Liang
March: Joe Johnson
April: Marco Ciufolini
May: Gary Pielak
October: Matthew Andrews
December: Andrew Skildum


November: Rui Wang
October: Marshall Hampton

Fleeting Glimpses of Lipid Rafts

Speaker: Dr. Anne Kenworthy; Associate Professor of Molecular Physiology & Biophysics, School of Medicine, Vanderbilt University

Time/Place: Thursday, Feb 17th at 3:00 pm, 130 SMed

Abstract: Lipid rafts are a class of membrane domains hypothesized to function in a wide range of processes, ranging from cell signaling to membrane trafficking events. A major challenge in the field remains how to best characterize lipid rafts, so that we can reach a mechanistic understanding of how they mediate their many proposed functions. I will summarize what our group has learned about the intrinsic structure and dynamics of rafts in live cells using techniques sensitive to protein and lipid diffusion. In addition, I will describe our recent studies of a specialized class of domains induced by "crosslinking" rafts, using cholera toxin B-subunit as a model. Together, these studies are allowing us to better define what comprises a lipid raft, and to begin to investigate structure-function relationships for this elusive class of membrane domains.

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