January: David D. Thomas
February: Elizabeth Austin-Minor
March: Juliette Lecomte
April: David Millar
May: Lukas Tamm
September: David Millar
September: Dongping Zhong
October: Jonathan V. Rocheleau
November: Yevgenya Grinblat
December: Michael Graner
Spectroscopic Probes of Muscle Protein Structural Dynamics
Speaker: David D. Thomas; Department of Biochemistry, Molecular Biology, and Biophysics,
University of Minnesota, Minneapolis, MN
Time/Place: Thursday, Jan. 19th at 3:00 pm, 130 SMed
Abstract: Through site-directed spectroscopy, we detect protein interactions, structural changes, and motions that are crucial to muscle contraction (myosin, actin, Ca release channels, troponin), relaxation (calcium pump, phospholamban), regulation (calmodulin, FKBP, PKA), and cytoskeletal resilience (dystrophin, utrophin).
Dr. Thomas will highlight new technology for time-resolved fluorescence and EPR, which create breakthroughs in structural resolution and high-throughput screening. These approaches are being applied to fundamental problems in muscle biophysics, and to the development of improved drug and gene therapies for heart failure and muscular dystrophy.