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ILSC Monthly Seminar: Thursday, November 15, 2012


January: Michael Taylor
February: Marna Yandeau-Nelson
March: Paul Lockman
April: Martin Gruebele


January: David D. Thomas
February: Elizabeth Austin-Minor
March: Juliette Lecomte
April: David Millar
May: Lukas Tamm
September: David Millar
September: Dongping Zhong
October: Jonathan V. Rocheleau
November: Yevgenya Grinblat
December: Michael Graner


January: Clay Carter
February (a): Anne Kenworthy
February (b): Jennifer Liang
March: Joe Johnson
April: Marco Ciufolini
May: Gary Pielak
October: Matthew Andrews
December: Andrew Skildum


November: Rui Wang
October: Marshall Hampton

Translating Pattern into Shape: Zebrafish Zic Genes in Craniofacial Morphogenesis

Speaker: Dr. Yevgenya Grinblat
Department of Zoology, University of Wisconsin-Madison
Thursday, November15, 2012; 3:00 PM / 130 SMed
Host: Dr. Jennifer Liang (joliang@d.umn.edu; x7681)

Abstract: Holoprosencephaly (HPE), the most common malformation of the human forebrain, is often associated with defects of the craniofacial skeleton. ZIC2, a zinc-finger transcription factor, is strongly linked to HPE in humans. We have identified important functions for zebrafish Zic2 both in the developing forebrain and the forming craniofacial skeleton in zebrafish, and are working to understand the mechanisms of these functions. Our data to date suggest that zebrafish Zic2 functions in two disparate aspects of craniofacial morphogenesis: (1) Neural crest specification and migration, and (2) early patterning of tissues surrounding craniofacial chondrogenic condensations.

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