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ILSC Monthly Seminar: Thursday, December 6, 2012


January: Michael Taylor
February: Marna Yandeau-Nelson
March: Paul Lockman
April: Martin Gruebele


January: David D. Thomas
February: Elizabeth Austin-Minor
March: Juliette Lecomte
April: David Millar
May: Lukas Tamm
September: David Millar
September: Dongping Zhong
October: Jonathan V. Rocheleau
November: Yevgenya Grinblat
December: Michael Graner


January: Clay Carter
February (a): Anne Kenworthy
February (b): Jennifer Liang
March: Joe Johnson
April: Marco Ciufolini
May: Gary Pielak
October: Matthew Andrews
December: Andrew Skildum


November: Rui Wang
October: Marshall Hampton

Spewing Fat Balls While Under Siege: Exosomes and the Unfolded Protein Response in Brain Tumors

Speaker: Dr. Michael Graner
Department of Neurosurgery, University of Colorado School of Medicine
Thursday, December 6, 2012; 3:00 PM / 130 SMed
Host: Lynne Bemis (ltbemis@d.umn.edu, x6775)

Abstract: Tumors are existentially stressed entities. Stresses of hostile growth environments lead to hypoxia, pH imbalance, and altered redox states; within a tumor cell, loss of intracellular checkpoints allows for genomic instability and production of mutated proteins leading to the burden of uncontrolled proliferation. Rather than succumbing to these stresses, however, tumors up-regulate stress responses that enable the tissues to survive and even thrive under harsh conditions. One such stress response is the Unfolded Protein Response (UPR), an endoplasmic reticulum-based cytoprotective mechanism acting to prevent the pathologies that accompany protein aggregation. Here we show that in high grade glioma (brain tumor) cells, the UPR changes exosome output, content, and activity, veritably passaging stress responses from stressed cells to naïve ones, and aiding in tumor cell metabolism, proliferation, migration, and chemotherapeutic resistance. Our data suggest a novel mechanism for stress conditioning with implications for tumor survival and treatment response resistance.

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