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ILSC Monthly Seminar: March 15, 2012


January: Michael Taylor
February: Marna Yandeau-Nelson
March: Paul Lockman
April: Martin Gruebele


January: David D. Thomas
February: Elizabeth Austin-Minor
March: Juliette Lecomte
April: David Millar
May: Lukas Tamm
September: David Millar
September: Dongping Zhong
October: Jonathan V. Rocheleau
November: Yevgenya Grinblat
December: Michael Graner


January: Clay Carter
February (a): Anne Kenworthy
February (b): Jennifer Liang
March: Joe Johnson
April: Marco Ciufolini
May: Gary Pielak
October: Matthew Andrews
December: Andrew Skildum


November: Rui Wang
October: Marshall Hampton

Cyanobacterial Hemoglobins: A New Light on an Ancient Family of Proteins

Speaker: Dr. Juliette Lecomte;
Department of Biophysics, Johns Hopkins University

Time/Place: Thursday, March 15th at 3:00 pm, 150 SMed

Abstract: Vertebrate globins have played prominent roles at several points in the history of molecular biology. They provided early evidence that proteins adopt native structures and that a single amino acid replacement could be the cause of disease. As sophisticated dioxygen transporters, they are at the basis of our understanding of cooperativity and allosteric change.  Globins, however, are an ancient family of proteins. They appear in many bacteria where they perform a variety of functions yet to be fully characterized. The presentation focues on the history of the globin fold and how it controls heme reactivity. Emphasis is placed on the application of nuclear magnetic resonance (NMR) spectroscopy to monomeric cyanobacterial hemoglobins and how the technique can be used to gain fundamental insight in ligand binding, protein dynamics, and electron transfer processes.

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