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ILSC Monthly Seminar: Thursday, January 24, 2013


January: Michael Taylor
February: Marna Yandeau-Nelson
March: Paul Lockman
April: Martin Gruebele


January: David D. Thomas
February: Elizabeth Austin-Minor
March: Juliette Lecomte
April: David Millar
May: Lukas Tamm
September: David Millar
September: Dongping Zhong
October: Jonathan V. Rocheleau
November: Yevgenya Grinblat
December: Michael Graner


January: Clay Carter
February (a): Anne Kenworthy
February (b): Jennifer Liang
March: Joe Johnson
April: Marco Ciufolini
May: Gary Pielak
October: Matthew Andrews
December: Andrew Skildum


November: Rui Wang
October: Marshall Hampton

Zebrafish as a model for the blood-brain barrier: A small fish tale

Speaker: Dr. Michael Graner
Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital
Thursday, January 24, 2013; 3:00 PM / 130 SMed
Host: Bjoern Bauer (bjbauer@d.umn.edu, x6036)

Abstract: The blood-brain barrier (BBB) plays a vital role in both normal and pathological processes within the central nervous system (CNS). Yet, a comprehensive understanding of the development and maintenance of this complex structure has been hampered by difficulties in observing the BBB in vivo and in performing unbiased genetic and small molecule screens. To overcome these limitations, we turned to zebrafish. Zebrafish provide a powerful tool for identifying genes and small molecules that play important roles in embryonic development and human disease, because the embryos develop rapidly outside of the mother, are easily manipulated genetically, and therapeutic compounds can be tested as supplements to the water in which the embryos develop. For this talk, I will introduce zebrafish as a model organism for the BBB, present a short story of how I became interested in studying the BBB, and discuss our progress toward answering fundamental questions in the field of brain barrier biology.

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