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ILSC Monthly Seminar: Thursday, March 28, 2013


January: Michael Taylor
February: Marna Yandeau-Nelson
March: Paul Lockman
April: Martin Gruebele


January: David D. Thomas
February: Elizabeth Austin-Minor
March: Juliette Lecomte
April: David Millar
May: Lukas Tamm
September: David Millar
September: Dongping Zhong
October: Jonathan V. Rocheleau
November: Yevgenya Grinblat
December: Michael Graner


January: Clay Carter
February (a): Anne Kenworthy
February (b): Jennifer Liang
March: Joe Johnson
April: Marco Ciufolini
May: Gary Pielak
October: Matthew Andrews
December: Andrew Skildum


November: Rui Wang
October: Marshall Hampton

Translating Difficulties into Opportunities in the Treatment of Brain Metastases of Breast Cancer

Speaker: Dr. Paul Lockman
Department of Pharmaceutical Sciences; Texas Tech University Health Sciences; Center School of Pharmacy; Amarillo, Texas
Thursday, March 28, 2013; 3:00 PM / 130 SMed
Host: Bjoern Bauer (bjbauer@d.umn.edu) x6036

Abstract: Brain metastases pose a significant problem for women with advanced metastatic diseases. The rate of brain metastasis has increased significantly in the last 10 years, approaching or exceeding 35% in subpopulations of metastatic breast cancer patients, particularly those with Her2+ or "triple-negative" tumors. After diagnosis of multiple metastatic lesions, patients typically die within one to two years. Unfortunately, treatment of brain metastases is primarily palliative due to limited curative effectiveness of radiation, surgery, and poor delivery of chemotherapy across the blood-brain barrier.

This talk focuses on why chemotherapy ultimately fails to treat brain metastases of breast cancer. However, new data suggests that we can to some degree prevent the metastatic process which would substantially improve survival times and quality of life.

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