Recent Publications:
Wallace, K.B. and Kemp, J.R. (1991). Species-Specificity in the Chemical Mechanisms of Organo-phosphorus Anticholinesterase Activity. Chem. Res. Toxicol. 4, 41-49.
Solem, L.E. and Wallace, K.B. (1993) Selective Activation of the Sodium-Independent, Cyclosporin A-Sensitive Calcium Pore of Cardiac Mitochondria by Doxorubicin. Toxicol. Appl. Pharmacol. 121, 50-57.
Trost, L.C. and Wallace, K.B. (1994). Stimulation of Myoglobin-Dependent Lipid Peroxidation by Adriamycin. Biochem. Biophys. Res. Comm. 204, 23-29.
Trost, L.C. and Wallace, K.B. (1994). Adriamycin-Induced Oxidation of Myoglobin. Biochem. Biophys. Res. Comm. 204, 30-37.
Solem, L.E., Henry, T.R. and Wallace, K.B. (1994). Disruption of Mitochondrial Calcium Homeostasis Following Chronic Doxorubicin Administration. Toxicol. Appl. Pharmacol. 129, 214-222.
Saxena, K., Henry, T.R., Solem, L.E. and Wallace, K.B. (1995). Enhanced Induction of the Mitochondrial Permeability Transition Following Acute Menadione Administration. Arch. Biochem. Biophys. 317, 79-84.
Henry, T.R., Solem, L.E. and Wallace, K.B. (1995). Channel-Specific Induction of the Cyclosporine A-Sensitive Mitochondrial Permeability Transition by Menadione. J. Toxicol. Env. Health 45, 489-504.
Henry, T.R. and Wallace, K.B. (1995) Differential Mechanisms of Induction of the Mitochondrial Permeability Transition by Quinones of Varying Chemical Reactivities. Toxicol. Appl. Pharmacol. 134, 195-203.
Henry, T.R. and Wallace, K.B. (1995) The Role of Redox Cycling Versus Arylation in Quinone-Induced Mitochondrial Dysfunction: A Mechanistic Approach in Classifying Reactive Toxicants. SAR QSAR Environ. Res. 4, 97-108.
Palmeira, C.M.M., Moreno, A.J.M., Madeira, V.M.C. and Wallace, K.B. (1996). Continuous Monitoring of Mitochondrial Membrane Potential in Hepatocyte Cell Suspensions. J. Pharmacol. Toxicol. Methods 35, 35-43.
Solem, L.E., Heller, L.J., and Wallace, K.B. (1996). Dose-Dependent Increase in Sensitivity to Calcium-Induced Mitochondrial Dysfunction and Cardiomyocyte Cell Injury by Doxorubicin. J. Mol. Cell. Cardiol. 28, 1023-1032..
Henry, T.R. and Wallace, K.B. (1996). Differential Mechanisms of Cell Killing by Redox Cycling and Arylating Quinones. Arch. Toxicol. 70, 482-489.
Serrano, J., Palmeira, C.M., Wallace, K.B. and Kuehl, D. Determination of 8-hydroxydeoxy-guanosine in biological tissue by liquid chromatography-electrospray ionization-mass spectrometry/ mass spectrometry. Rapid Commun. Mass Spec. (in press)
Palmeira, C.M. and Wallace, K.B. Benzoquinone inhibits oxidative transformations in the voltage-dependent regulation of the mitochondrial permeability transition by naphthoquinones. (submitted)
Invited Reviews and Book Chapters:
Wallace, K.B. "Species-Selective Toxicity of Organophosphorus Insecticides: A Pharmacodynamic Phenomenon." (Chapter 4, pp 79-105). In: Organophosphates: Chemistry, Fate and Effects (eds., J.E. Chambers and P.E. Levi). Academic Press, Inc., San Diego, CA (1992).
Wallace, K.B. and Kemp, J.R. 'Molecular Mechanisms Governing the Species-Selective Inhibition of Acetylcholinesterase by Organophosphorus Insecticides." In: 1991 Yearbook of Pharmacology.
Wallace, K.B. " Oxygen Free Radical-Independent Generation of Aldehyde Products of Microsomal Lipid Peroxidation by Adriamycin." (pp. 569-576) In: Oxidative Damage & Repair: Chemical, Biological, and Medical Aspects (K.J.A. Davies, ed.). Pergamon Press, Inc. (1992).
Wallace, K.B. "Free Radical-Mediated Cardiac Toxicity." (Chapter 14) In: Free Radical Toxicology: The Target Organ Toxicology Series (ed., K.B. Wallace). Raven Press (in press).
Wallace, K.B., Eells, J.T., Madeira, V.M.C., Stevens, J.L., Cortopassi, G. and Jones, D.P. "Mitochondrial-Mediated Cell Injury." Fundamental and Applied Toxicology (in press).
Palmeira, C.M., Madeira, V.M.C., Moreno, A.J.M. and Wallace, K.B. "Bioenergetics of Mitochondrial-Mediated Cytotoxicity." Critical Reviews in Toxicology (in press).
Technical Reports:
Fischer, L.J., P.M. Bolger, G.P. Carlson, J.L. Jacobson, B.A. Knuth, M.J. Radike, M.A. Roberts, P.T. Thomas, K.B. Wallace and K.G. Harrison. 1995. Critical Review of a Proposed Uniform Great Lakes Fish Advisory Protocol, August, 1995. Michigan Environmental Science Board, Lansing.
Abstracts:
Trost, L.C. and Wallace, K.B. Doxorubicin Induced Aldehyde Formation and Glutathione Depletion in Cardiac Microsomes. The Toxicologist 11:220, 1991.
Solem, L.E. and Wallace, K.B. Calcium-Dependent Inhibition of Mitochondrial Respiration by Doxorubicin. The Toxicologist 11:304, 1991.
Wallace, K.B. and Kemp, J.R. Species-Specific Physical Chemical Determinants of Organo-phosphorus Anticholinesterase Activity. The Toxicologist 11:559, 1991.
Solem, L.E. and Wallace, K.B. Disruption of Cardiac Mitochondrial Calcium Homeostasis by Doxorubicin. The Toxicologist 12:1493, 1992.
Trost, L.C. and Wallace, K.B. Adriamycin-Induced Alterations in the Oxidation State of Myoglobin. The Toxicologist 13:369, 1993.
Wallace, K.B. and Trost, L.C. Stimulation of Myoglobin-Dependent Lipid Peroxidation by Adriamycin. The Toxicologist 13:370, 1993.
Solem, L.E. and Wallace, K.B. Doxorubicin-Induced Mitochondrial Calcium Release Associated with Enhanced Oxygen Free Radical Production. The Toxicologist 13:371, 1993.
Henry, T.R. and Wallace, K.B. Calcium Channel-Specific Effects of Menadione in Rat Liver Mitochondria. The Toxicologist 13:1626, 1993.
Trost, L.C. and Wallace, K.B. Adriamycin Stimulates Myoglobin-Dependent Lipid Peroxidation. Molecular and Cellular Biochemistry of Oxidative Stress. Urbino, Italy, 1993.
Henry, T.R. and Wallace, K.B. Selective Stimulation of Cyclosporine A-Sensitive Calcium Release from Mitochondria by Menadione. Workshop: New Perspectives in Mitochondrial Research, Padova, Italy, 1993.
Solem, L.E. and Wallace, K.B. Selective Stimulation of Mitochondrial Calcium Release by Adriamycin. 2nd International Union of Biochemistry and Molecular Biology. Bari, Italy, 1993.
Solem, L.E. and Wallace, K.B. Effect of Chronic Doxorubicin Treatment on Cardiac Mitochondrial Calcium Homeostasis. The Toxicologist 14:596, 1994.
Henry, T.R. and Wallace, K.B. Redox Cycling Versus Arylation in Quinone-Induced Loss of Mitochondrial Calcium Homeostasis. The Toxicologist 14:614, 1994.
Saxena, K., Henry, T.R. and Wallace, K.B. Effects of In Vivo Menadione on Mitochondrial Respiration and Calcium Homeostasis. The Toxicologist 14:617, 1994.
Henry, T.R. and Wallace, K.B. The Role of Redox Cycling Versus Arylation in Quinone-Induced Mitochondrial Dysfunction. Sixth International Workshop on Quantitative Structure-Activity Relationships (QSAR) in Environmental Sciences. Sept. 13-17, 1994, Belgirate, Italy.
Henry, T.R., Palmeira, C.M. and Wallace, K.B.: Differential Mechanisms of Cell Killing by Redox Cycling and Arylating Quinones. The Toxicologist 15:155, 1995.
Palmeira, C.M., Henry, T.R., Moreno, A.J., Madeira, V.M.C. and Wallace, K.B. Measurement of Mitochondrial Membrane Potential in Isolated Hepatocytes: A New Approach. The Toxicologist 15:156, 1995.
Solem, L.E., Heller, L.J. and Wallace, K.B. Dose-Dependent Mitochondrial Cardiomyopathy Associated with In Vivo Adriamycin. IUTOX, International Congress of Toxicology - VII. No. 88-P-2. Seattle, WA, July 2-6, 1995.
Palmeira, C.P. and Wallace, K.B. The Mitochondrial Permeability Transition Caused by Menadione is Inhibited by Benzoquinone. Fund. Appl. Toxicol. 30:1237, 1996.
Wallace, K.B., Eells, J.T., Madeira, V.M.C., Stevens, J.L., Cortopassi, G.A. and Jones, D.P. Quinone-Induced Interference with Mitochondrial Calcium Regulation. Fund. Appl. Toxicol. 30:1130, 1996.
Wallace, K.B. Adriamycin-Induced Mitochondrial Cardiomyopathy. Biochim. Biophys. Acta EBEC Short Reports 9:C.IV-4, 1996.
Palmeira, C.M. and Wallace, K.B. Benzoquinone Inhibits the Oxidant-Induced Shift in Voltage Gating Potential of the Mitochondrial Permeability Transition Pore Caused by Naphthoquinones. Frontiers in Mitochondrial Research. Rensselaerville Conference Center, NY, September 20-22, 1996.
Palmeira, C.M., J. Serrano, Kuehl, D.W. and Wallace, K.B. Cardioselective Accumulation of g-hydroxydeoxyguanosine Adducts of Mitochondrial DNA Following Acute Doxorubicin Administration. Society of Toxicology, 1997.
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