CHEMICAL HYGIENE PLAN

UMD Logo
College of Science and Engineering
Department of Chemical Engineering
PREVIOUS
NEXT


Table 5. Carcinogens, Reproductive Toxins or Highly Toxic Chemicals

The chemicals listed below are extremely hazardous. Workers must have knowledge of the dangers of these chemicals prior to use, and documentation of training in safe working procedures.

  • Biologically active compounds
    • protease inhibitors (e.g. PMSF, Aprotin, Pepstatin A, Leopeptin);
    • protein synthesis inhibitors (e.g. cycloheximide, Puromycin);
    • transcriptional inhibitors (e.g. alpha-amanitin and actinomycin D);
    • DNA synthesis inhibitors (e.g. hydroxyurea, nucleotide analogs (i.e. dideoxy nucleotides, actinomycin D, acidicolin);
    • phosphatase inhibitors (e.g. okadaic acid);
    • respiratory chain inhibitors (e.g. sodium azide);
    • kinase inhibitors (e.g. NaF);
    • mitogenic inhibitors (e.g. coicemid);
    • and mitogenic compounds (e.g. concanavalin A).
  • Castor bean (Ricinus communis) lectin: Ricin A, Ricin B, RCA toxins
  • Diisopropyl fluorophosphate: highly toxic cholinesterase inhibitor; the antidote, atropine sulfate and 2-PAM (2-pyridinealdoxime methiodide) must be readily available
  • Jaquirity bean lectin (Abrus precatorius)
  • N-methyl-N'-nitro-N-nitrosoguanidine: carcinogen (this chemical forms explosive compounds upon degradation)
  • Phalloidin from Amanita Phalloides: used for staining actin filaments
  • Retinoids: potential human teratogens
  • Streptozotocin: potential human carcinogen
  • Urethane (ethyl carbamate): an anesthetic agent, potent carcinogen and strong teratogen, volatile at room temperature



PREVIOUS NEXT INDEX

This web page (http://www.d.umn.edu/~dlong/chp/chptabl5.html) is maintained by Duane Long, Department of Chemical Engineering, and was last updated 29-Oct-1999.