Adaptive evolution is a unique concept because it applies so widely across the biological field.  It can occur on a very small scale, in amino acid sequence, as well as at a very large scale in an entire population of organisms.  This range in scale also applies to time, as evolution can occur very quickly as well as very slowly.  Evolution as described in this paper is occurring very quickly and at a small scale, in the HIV virus, as well as the more slowly and at a slightly large scale in the human immune response.  As is seen with most HIV patients, the virus tends to evolve much more quickly and will eventually win the race.