Integrated Evolutionary Processes

Williamson 2003. Adaptation in the env Gene of HIV-1 and evolutionary theories of disease progression. Mol. Biol. Evol. 20(8):1318-1325.

QQQ

· What hypothesis do the authors propose to explain the rapid evolutionary rate of the HIV-1 env gene?

· Why is it expected that synonymous and nonsynonymous substitutions should occur at different rates?

· How do genetic differences among people influence the duration of the asymptomatic period?

· What is the scale of adaptive evolution?