Sigalov. 2012. Evolution of immunity: no development without risk.

Immunol Res (2012) 52:176–181



1.      What is are the hypothesized evolutionary advantages and disadvantages of separating recognition and signaling functions for MIRRs?

2.      What is meant by “intrinsic protein disorder” and why does the author propose that is apparently chaotic condition is evolutionary advantageous?

3.      This paper presents features that are more fixed and more plastic.  Describe what they are and why both are advantageous in the context of the immune system.

4.      What are homoooooooooooooligomers?  J Don’t answer this one!