2014 Antineoplastics

DRUGS THAT INTEREFERE WITH ANGIOGENESIS

INTERLEUKIN 12

  • works through a number of other processes separate from its role in driving Th cell differentiation and influencing adaptave immunity

  • induces interferon γ, resulting in the production of inducible protein 10 (IP-10 or CXCL10), which actually mediates the anti-angiogenic response

  • common side effects include: fever/chills, nausea/vomiting, headache

  • more severe toxicities include: fever, anemia, thrombocytopenia, neutropenia, leukopenia - limiting toxities are stomatitis and abnormal liver function tests
    • pre-dosing (giving a single dose, followed by several weeks of rest before continuing with more intensive treatment) may decrease these toxicities
Email: Dr. Janet Fitzakerley | ©2014 University of Minnesota Medical School Duluth | Last modified: 6-may-14 7:28 AM