2015 Antineoplastics

Drugs that inhibit androgen receptors: BICALUTAMIDE, FLUTAMIDE, NILUTAMIDE

Androgen deprivation therapy (ADT) is the mainstay of prostate cancer treatment, and is usually induced medically by administration of GnRH analogues such as GOSERELIN or LEUPROLIDE.  Non-steroidal anti-androgens (NSAAs; i.e., the "LUTAMIDES") are typically given short term, in order to prevent the “flare” response observed when GnRH agonists are first given to prostate cancer patients.  This drug combination (NSAA + GnRH agonist) results in complete androgen blockade (CAB).
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Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM