2014 Antineoplastics

Drugs that inhibit androgen receptors: BICALUTAMIDE, FLUTAMIDE, NILUTAMIDE

Androgen deprivation therapy (ADT) is the mainstay of prostate cancer treatment, and is usually induced medically by administration of GnRH analogues such as GOSERELIN or LEUPROLIDE.  Non-steroidal anti-androgens (NSAAs; i.e., the "LUTAMIDES") are typically given short term, in order to prevent the “flare” response observed when GnRH agonists are first given to prostate cancer patients.  This drug combination (NSAA + GnRH agonist) results in complete androgen blockade (CAB).
Critical fact icon

Mechanism

Email: Dr. Janet Fitzakerley | ©2014 University of Minnesota Medical School Duluth | Last modified: 6-may-14 7:28 AM