2015 Antineoplastics

Cell cycle was presented by Dr. Holy in Foundations.

Cancer drugs can be divided into two general classes:  CELL CYCLE SPECIFIC DRUGS (CCS; esp. plant alkaloids and antimetabolites), and CELL CYCLE NON-SPECIFIC DRUGS (CCNS; esp. alkylating agents and some natural products).  Antineoplastic agents can also be organized according to their chemical class, mechanism of action, therapeutic use or their toxicities. Critical Fact Icon
  • Cell Cycle Diagramall cells (normal and neoplastic) progress through the cell cycle

  • cells spend a different percentage of time in each portion of the cell cycle
    • the percentages indicated in the figure are typical for a neoplastic cell
    • in particular, the duration of both G0 and G1 can vary dramatically

  • Example Questiondrugs that act only during a specific portion of the cell cycle (CCS drugs) will be least effective at treating cancers who have low growth fractions (i.e., most of the cells are in G0)

  • it is common to follow treatment with a CCNS drug with a CCS drug, so that cancer cells are recruited into the cell cycle, where CCS drugs can be more effective
  • only proliferating cells killed (high growth factor tumors preferentially eliminated)
  • both proliferating and non-proliferating cells killed (attack both high and low growth factor tumours)
  • schedule dependent
    (duration and timing matter in addition to dose)
  • dose dependent
    (total dose matters more than schedule)





Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 4-may-15 3:01 PM