Buffer acid
ALUMINUM HYDROXIDE, CALCIUM CARBONATE, MAGNESIUM HYDROXIDE, SODIUM BICARBONATE
-
antacids are very safe drugs, particularly with short-term use
-
side effects are minimized by designing agents that are not systemically absorbed (SODIUM BICARBONATE is the exception)
-
patients with renal insufficiency are more likely to experience serious side effects
- because of their low degree of systemic absorption and the efficiency of the neutralization reaction (à lower chance of metabolic alkalosis), ALUMINUM and MAGNESIUM HYDROXIDE have a much lesser incidence of serious side effects (if given together, their "lower GI" effects" offset each other)
DRUG |
ADVANTAGES |
DISADVANTAGES |
SERIOUS (but extremely rare) SIDE EFFECTS |
ALUMINUM HYDROXIDE |
|
|
|
MAGNESIUM HYDROXIDE |
|
|
|
CALCIUM CARBONATE |
|
|
|
SODIUM BICARBONATE |
|
|
|
|