2014 Inner Ear Physiology

Stereocilia tiplinks & transduction channels

  • protein bridges join adjacent stereocilia at several levels; the most critical are those found at the apex of the stereocilia (the tiplinks)

  • transduction channels are thought to be directly connected to the tiplink

  • stereocilia movement changes the tension in the tiplink, resulting in opening or closing of the transduction channel

  • K+ flows through open channels (see discussion of the endocochlear potential) and depolarizes the hair cell

http://www.nidcd.nih.gov/news/stories/04/04_19_04.asp#note1

EM of stereocilia tip links

Model of hair cell transduction
Email: Dr. Janet Fitzakerley | ©2014 University of Minnesota Medical School Duluth | Last modified: 15-feb-14 9:04 PM