2014 Ion Channel Physiology

Electrochemical Gradients

Chemical Gradients

Electrolyte Concentrations
in Plasma (mEq/L)
Na+
136-145
K+
3.5-5.0
Ca2+
1-2
Cl-
95-105
Intracellular Ion Concentrations (mM)
 
Myocyte
Neuron
Na+
10
5-15
K+
155
140 mM
Ca2+
0.0001 mM
0.0001 mM
Cl-
10-20
4-30 mM
Critical Fact Icon The primary function of neuronal Na+/K+ ATPase is the establishment of the concentration gradients for Na+ and K+ that are used to establish the resting, graded and action potentials of neurons and myocytes. The actions of Na+/K+ ATPase are only mildly electrogenic: the net result of the actions of Na+/K+ ATPase is a Vm of ~ -5 to -12 mV.

Electrical Gradients

Email: Dr. Janet Fitzakerley | ©2014 University of Minnesota Medical School Duluth | Last modified: 20-sep-14 10:16 AM