2014 Sensory Physiology

Critical factTransduction

Olfactory Transduction Mechanism
  • as in the visual and gustatory systems, olfactory transduction consists of 4 steps:

    1. activation of the receptor protein (R)
      • olfactants are chaperoned to the receptor by olfactory binding proteins
    2. the activated receptor stimulates a G-protein, Golf
    3. Golf activates an effector protein, adenylate cyclase III, that increases cAMP concentrations
    4. increases in cAMP cause the opening of non-specific ligand-gated cation channels, which leads to depolarization
Email: Dr. Janet Fitzakerley | ©2014 University of Minnesota Medical School Duluth | Last modified: 4-feb-14 8:26 PM