2014 Sensory Physiology

Transduction

Transduction is the unique physiological process
that is common to all sensory systems.

DEFINITION: Conversion of stimulus energy to electrical potentials

multistep process (steps in grey are optional):
STIMULUSaccessory structures
RECEPTOR:  conformational change in transducer protein
2nd messenger systems
ion channel activation/inactivation (conductance change)
receptor potential
neurotransmitter release
action potential in primary afferent

Critical Fact Icon
Hair cell transduction currents
AUDITORY SYSTEM EXAMPLE
(hair cell currents and receptor potential)
Receptor potential in response to sinusoidal stimulus
Transduction currents recorded from a hair cell in response to stereocilia deflection.
Hair cell receptor potential in response to a sinusoidal stimulus.


The stages in the auditory transduction process are:

SOUND external/middle/inner ear (esp. organ of Corti in the cochlea) HAIR CELL:  mechanotransduction channel opens or closes → receptor potential in hair cell (depolarization/hyperpolarization) → neurotransmitter releasechange in action potential frequency in auditory nerve fibre

 

 

Email: Dr. Janet Fitzakerley | ©2014 University of Minnesota Medical School Duluth | Last modified: 4-feb-14 8:26 PM