2015 Antineoplastics

Types

I. INTERLEUKIN 12

II. INTERFERON α

III. VEGF and VEGF-R inhibitors

• BEVACIZUMAB is an anti-VEGF antibody
  
• PAZOPANIB, SORAFENIB and SUNITINIB are signal transduction inhibitors that block the actions of VEGF and PDGF
  

IV. mTOR inhibitors

• EVEROLIMUS and TEMSIROLIMUS are immunosuppressive antibiotics that function as mTOR inhibitors

V. THALIDOMIDE

• Drug cards
• Types of Antiangiogenics
• Interleukin 12
• Interferon α
• Role of VEGF and mTOR
• VEGF & VEGF-R inhibitors
  • Bevacizumab
  • VEGF-R-inhibiting STIs
• mTOR inhibitors
  • Mechanism
  • Pharmacokinetics
  • Therapeutic uses
  • Toxcity
• Thalidomide
  • Mechanism of action
  • Pharmacokinetics
  • Therapeutic uses
  • Toxicity
    • Phocomelia