2015 Antineoplastics

INTERLEUKIN 12

• works through a number of other processes separate from its role in driving T_h cell differentiation and influencing adaptave immunity

• induces interferon γ, resulting in the production of inducible protein 10 (IP-10 or CXCL10), which actually mediates the anti-angiogenic response

• common side effects include: fever/chills, nausea/vomiting, headache

• more severe toxicities include: fever, anemia, thrombocytopenia, neutropenia, leukopenia - limiting toxities are stomatitis and abnormal liver function tests
  • pre-dosing (giving a single dose, followed by several weeks of rest before continuing with more intensive treatment) may decrease these toxicities