2015 Antineoplastics

Role of VEGF and mTOR in angiogenesis

Angiogenesis inhibitor mechanisms

Cancer cells can stimulate angiogenesis, thereby facilitating their own growth. A key component of the intracellular signaling pathways is mTOR, which is involved in growth of both the cancer and the vascular cells.

Most angiogenesis inhibitors work by decreasing the actions of substances that promote angiogenesis, particularly VEGF and mTOR.

The only exception is INTERLEUKIN 12, which increases the actions of a native angiogenesis inhibitor
(inducible protein 10).

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Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM