2015 Antineoplastics


Critical Fact IconMechanisms of Action

A. Reducing cell growth and proliferation

  1. Decreased cell cycle progression
    • mTOR regulates protein synthesis of cyclin D1, which controls progression through the G1/S checkpoint → mTOR inhibition slows cell growth
      • this may be particularly important in cancer cells characterized by overexpression of cyclin D1 (e.g., mantle cell lymphoma)

  2. Reduced bioenergetics
    • cancer cells rely on glycolysis to provide ATP for sustained growth
    • mTOR increases expression of amino acid and glucose transporters, which are upregulated in several cancers → mTOR inhibition decreases access to nutrient and metabolic fuel → decreased cell growth

B. Prevention of angiogenesis

C. Increased cytotoxicity of drugs that damage DNA

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM