Interrupt mitosis DRUGS THAT INTERRUPT MITOSIS
(antimitotics, spindle poisons)
Chemical Types
Plant alkaloids
I. Vinca alkaloids: VINBLASTINE, VINCRISTINE, VINORELBINE (there are others)
II. Taxanes: CAPAZITAXEL, DOCATAXEL, PACLITAXEL (there are others)
Antibiotic
III. Epilone: IXABEPILONE
The vinca alkaloids (VINCRISTINE and VINBLASTINE), the taxanes (PACLITAXEL) and the epilones (IXABELPILONE) are CCS drugs (M phase) that act as mitotic spindle poisons. Despite their structural similarity, VINCRISTINE and VINBLASTINE have significantly different uses and toxicities. |
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