2015 Antineoplastics

B. PYRIMIDINE ANALOGUES : 5-FLUOROURACIL, CAPECITABINE

5-FLUOROURACIL and CAPECITABINE decrease the biosynthesis of pyrimidine nucleotides by inhibiting thymidylate synthase, the enzyme that catalyzes the rate limiting step in DNA synthesis.  This results in the “thymineless death” of rapidly growing cells.

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5-Fluorouracil structureMechanisms of Action

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM