2015 Antineoplastics

Types (all are antimetabolites)

1. Folic acid analogues: METHOTREXATE, PEMETREXED, PRALATREXATE
• LEUCOVORIN (supporting agent used for rescue)


2. Pyrimidine analogues: 5-FLUOROURACIL (5-FU), CAPECITABINE


3. Purine anaologues: 6-MERCAPTOPURINE, 6-THIOGUANINE
   • ALLOPURINOL (supporting agent used to prevent hyperuricemia)

• Drug cards
• Nucleotide biochemistry
• Types
• Nucleotide synthesis inhibitors
  • Folic acid analogues
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
    • Leucovorin rescue
  • Pyrimidine analogues
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
  • Purine analogues
    • Review of purine synthesis
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
    • Tumour lysis syndrome
• DNA synthesizing enzyme inhibitors