2015 Antineoplastics

DRUGS THAT PREVENT DNA SYNTHESIS

Antimetabolites are analogues of folate, pyrimidines or purines that interfere with key enzymes used during nucleotide synthesis.  ALL of these agents are CELL CYCLE SPECIFIC (CCS), as their effects occur during S phase.  A common mechanism for the development of resistance to these agents is modification of the target enzymes.  
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Classification by Mechanism (labels):

I. Nucleotide synthesis inhibitors

II. Drugs that block DNA synthesizing enzymes

III. Supporting agents

Classification by Chemical Class (cards):

I. Antimetabolites (structural analogues):

5-FLUOROURACIL (5-FU) [CAPECITABINE], 6-MERCAPTOPURINE [AZOTHIOPRINE], 6-THIOGUANINE, ALLOPURINOL, CLADRIBINE, CYTARABINE, FLUDARABINE, GEMCITABINE, LEUCOVORIN, METHOTREXATE, PEMETREXED, PRALATREXATE

II. Miscellaneous: HYDROXYUREA

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 4-may-15 9:26 PM