Prevent DNA synthesisDRUGS THAT PREVENT DNA SYNTHESIS
Antimetabolites are analogues of folate, pyrimidines or purines that interfere with key enzymes used during nucleotide synthesis. ALL of these agents are CELL CYCLE SPECIFIC (CCS), as their effects occur during S phase. A common mechanism for the development of resistance to these agents is modification of the target enzymes. |
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Classification by Mechanism (labels):
I. Nucleotide synthesis inhibitors
II. Drugs that block DNA synthesizing enzymes
III. Supporting agents
Classification by Chemical Class (cards):
I. Antimetabolites (structural analogues):
5-FLUOROURACIL (5-FU) [CAPECITABINE], 6-MERCAPTOPURINE [AZOTHIOPRINE], 6-THIOGUANINE, ALLOPURINOL, CLADRIBINE, CYTARABINE, FLUDARABINE, GEMCITABINE, LEUCOVORIN, METHOTREXATE, PEMETREXED, PRALATREXATE
II. Miscellaneous: HYDROXYUREA