A. Folic acid analogues
Types
-
Nucleotide synthesis inhibitors: METHOTREXATE, PEMETREXED, PRALATREXATE
- other antifolates are on the market or in development; like PEMETREXED, they are designed to have a higher affinity for the reduced folate carrier and for the formation of polyglutates
- Supporting agent: LEUCOVORIN (used for rescue)