2015 Antineoplastics

Types

1. Nucleotide synthesis inhibitors: METHOTREXATE, PEMETREXED, PRALATREXATE

   • other antifolates are on the market or in development; like PEMETREXED, they are designed to have a higher affinity for the reduced folate carrier and for the formation of polyglutates


2. Supporting agent: LEUCOVORIN (used for rescue)

• Drug cards
• Nucleotide biochemistry
• Types
• Nucleotide synthesis inhibitors
  • Folic acid analogues
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
    • Leucovorin rescue
  • Pyrimidine analogues
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
  • Purine analogues
    • Review of purine synthesis
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
    • Tumour lysis syndrome
• DNA synthesizing enzyme inhibitors