2015 Antineoplastics

A. FOLIC ACID ANALOGUES: METHOTREXATE, PEMETREXED, PRALATREXATE

Resistance

      1. production of DHFR with a decreased affinity
      2. increased DHFR expression
      3. decreased formation of poly-G/MTX
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM