2015 Antineoplastics

Therapeutic Uses

METHOTREXATE

• broad spectrum

• acute leukemias (provided first ever temporary remission in 1948)

• solid tumours, including choriocarcinoma (1st ever cure of a solid tumour in 1963), and breast cancer (part of CMF regimen)

PEMETREXED

• mesothelioma and non-small cell lung cancer (NSCLC)

• Drug cards
• Nucleotide biochemistry
• Types
• Nucleotide synthesis inhibitors
  • Folic acid analogues
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
    • Leucovorin rescue
  • Pyrimidine analogues
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
  • Purine analogues
    • Review of purine synthesis
    • Mechanism of action
    • Resistance
    • Pharmacokinetics
    • Therapeutic Uses
    • Toxicity
    • Tumour lysis syndrome
• DNA synthesizing enzyme inhibitors