C. PURINE ANALOGUES : 6-MERCAPTOPURINE (6-MP), 6-THIOGUANINE (6-TG)
Toxicity
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primary toxic effects are on bone marrow
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anorexia, nausea and vomiting occur in 25% of adults; less often in children
- as with any drugs used to treat leukemias, can cause TUMOUR LYSIS SYNDROME