2015 Antineoplastics

DIFFERENTIATING AGENTS

ARSENIC TRIOXIDE (ATO)

  • heavy metal toxin that promotes cell death through both apoptosis and necrosis

  • given in conjunction with TRETINOIN to cause death of differentiated granulocytes

  • also approved for relapsed APL (complete responses in 85% of patients)

  • generally well tolerated, but toxicities include:
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 10-may-15 8:52 PM