Differentiating agents / Bexarotene
DIFFERENTIATING AGENTS
BEXAROTENE
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rexinoid that selectively activates retinoid X receptors, which are involved in the regulation of cell growth and differentiation
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approved for use in patients with cutaneous T-cell lymphoma that is refractory to skin-directed treatment
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metabolized by CYP3A4 (potential for many drug interactions)
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side effects include: GI symptoms, lipid abnormalities and pancreatitis (must monitor blood lipid levels)
- TERATOGENIC