Drugs that disrupt DNA / Crosslinking agents / Common toxicities
I. Crosslinking agents
Common toxicities
- generally, less for oral agents and greatest for MECHLORETHAMINE
- moderate to severe myelosuppression
- severe nausea and vomiting
- strong vesicant (blistering) properties (not for oral agents)
- particularly a problem when the crosslinking agent escapes from the vein it's being injected into (extravasation; try searching for images using this as a search term)
- immunosuppression
- gonadal failure (sterility)
- carcinogeneisis (leukemias, esp. AML)
- mutagenesis
- teratogenesis