Specifics of Platinum containing compounds (CISPLATIN, CARBOPLATIN, OXALOPLATIN)
- CARBOPLATIN and OXALOPLATIN have less kidney and GI side effects than CISPLATIN
PHARMACOKINETICS
- hydration with saline infusion and potent antiemetics required
THERAPEUTIC USES
- testicular cancer (PVB regimen)
- many solid cancers
TOXICITIES
-
most potent emetic antineoplastic drug
-
kidney
-
ototoxic
-
peripheral neuropathy
- heart (EKG changes, angina)