Disrupt DNA CYCLOPHOSPHAMIDE (IFOSFAMIDE) Specifics
- IFOSFAMIDE acts more slowly and different therapeutic uses from CYCLOPHOSPHAMIDE
PHARMACOKINETICS
-
oral
- cytochrome P450 activation
THERAPEUTIC USES
-
very broad spectrum (lymphomas, leukemias, myelomas, sarcomas, breast, lung and ovarian cancers)
- regimens:
- CHOP: non-Hodgkin's lymphoma
- CMF/FAC: breast cancer
TOXICITIES
- HEMORRHAGIC CYSTITIS (lifethreatening damage to bladder epithelium) due to acrolein
- treated with MESNA and adequate hydration
- heart
- liver
- IFOSFAMIDE is the most neurotoxic of the alkylating agents, causing altered mental status, generalized seizures, paralysis and coma