2015 Antineoplastics

Resistance

• decreased accumulation via increased P-glycoprotein à multidrug resistance

• changes in target proteins

  • decreased topoisomerase II activity (i.e., decreased DNA synthesis)

• increased inactivation
• increased glutathione peroxidase activity (i.e., protection against oxidative damage)

• Drug cards
• Types
• Crosslinking agents
  • Mechanism of action
  • Common Resistance Mechanisms
  • Pharmacokinetics
  • Therapeutic uses
  • Common toxicities
  • Unique Properties of Key Drugs
    • Mechlorethamine
    • Cyclophosphamide
    • Nitrosoureas
    • Cisplatin
  • Quirky Properties of Other Drugs
    • Busulfan
    • Dacarbazine
    • Chlorambucil
    • Melphalan
    • Mitomycin
    • Temozolamide
• Intercalating agents
  • Mechanism of action
  • Resistance
  • Pharmacokinetics
  • Therapeutic uses
  • Toxicity
• Drugs that cause strand breaks
  • Mechanisms of action
    • Bleomycin
    • Topoisomerase inhibitors
      • Topo review
    • Miscellaneous
  • Resistance
    • Bleomycin
    • Etoposide
    • Irinotecan
  • Therapeutic uses
  • Toxicity
    • Bleomycin
    • Etoposide
    • Irinotecan