2015 Antineoplastics

II. Intercalating agents: ANTHRACYCLINE ANTIBIOTICS

Critical facts icon

Toxicities

 

  1. Cardiomyopathy:
    • Acute: increased heart rate, conduction abnormalities, arrhythmias
    • Delayed: congestive heart failure that is unresponsive to digitalis (may occur years after treatment)

  2. Extravasation à necrosis (vesicant)

  3. Myelosuppression is major dose-limiting complication (individual course of treatment)

  4. Nausea and vomiting

  5. Alopecia

  6. Mutagenic, carcinogenic

  7. "Radiation recall reaction" - erythema and desquamation of the skin at sites of prior radiation therapy

  8. Hand-foot syndrome (palmar-plantar erythrodysesthesia)

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM