2015 Antineoplastics

III. Drugs that cause DNA strand breaks


  • decreased accumulation via increased P-glycoprotein (à multidrug resistance)

  • changes in target proteins
    • mutation or decreased expression of topoisomerase II
    • decreased apoptosis due to mutation of p53
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM