2015 Antineoplastics

2. Antibiotics: CYCLOSPORINE, EVEROLIMUS, TACROLIMUS, TEMSIROLIMUS

Immunosuppressive antibiotics are used to prevent rejection following bone marrow transplants (CYCLOSPORINE, TACROLIMUS) and as angiogenesis inhibitors (EVEROLIMUS, TEMSIROLIMUS).  These drugs are involved in 2 pathways that are involved in cell proliferation:  1) NFAT-mediated regulation of interleukin synthesis and 2) mTOR regulation of cell growth and angiogenesis Critical fact icon

Mechanisms of action

Antirejection

Pathway 1

Anti-angiogenesis and anti-proliferation

Pathway 2

 

N.B. A 3rd pathway for regulation of growth factor/cytokine expression is shown on the diagram

Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM