2015 Antineoplastics

1. Glucocorticoids: DEXAMETHASONE, PREDNISONE

Mechanism of action (immune system)

The glucocorticoids DEXAMETHASONE and PREDNISONE, are used as immunosuppressants in the treatment of many types of cancers --- specifically those that express the requisite receptors (e.g., prednisone-sensitive lymphomas).  When used in cancer chemotherapy, these agents are given in higher doses, using a “pulse” regimen, compared to their use in treating inflammatory diseases (asthma, arthritis, lupus, etc.).
Critical facts icon
Cancer cells
Normal immune system
Trigger for cell division
Unstimulated
Specific antigen
Cell division
Random
Synchronized
Chemotherapy
Immunosuppression
Drug administration
High dose, "pulse"
Low dose, continuous
Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 10-may-15 2:42 PM