2015 Antineoplastics

2. Hematopoietic agents (supporting factors)

Bone marrow suppression is the dose-limiting complication of many antineoplastic drugs.  Recombinant forms of several lineage-dependent colony stimulating factors have been developed.  These factors activate specific progenitor cells, resulting in the production of:  ERYTHROPOIETIN à red blood cells, FILGRASTIM (G-CSF) à neutrophils, SAGRAMOSTIM (GM-CSF) à granulocytes, eosinophils, basophils and monocytes and INTERLEUKIN 11 and ROMIPLOSTIM à platelets.

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Email: Dr. Janet Fitzakerley | ©2015 University of Minnesota Medical School Duluth | Last modified: 11-apr-15 9:39 AM